Set in an Irish neighbourhood in Providence, the series reflects around two brothers on opposite sides of the law: one a gangster (Jason Isaacs) and the other a politician (Jason Clarke).

Brotherhood follows the lives of two brothers in the Providence, Rhode Island Irish-American neighbourhood known as “The Hill”. The blue-collar neighbourhood has roots in old-world ways of street justice and shady dealings. Tommy Caffee (Jason Clarke) is a family man and local politician who is out to protect the community and its best interests. His world is turned around when his gangster brother Mike (Jason Isaacs) returns to “The Hill” to regain control of the seedy underworld.