Detective Mac Taylor discovers the body of a missing woman in Brooklyn Heights. When he discovers a second victim on a garbage barge, his investigation leads him to a serial killer who “imprisons” his victims. Grappling with memories of his own wife, Taylor follows the killer’s trail to a live victim. A woman who cannot move, feel, or speak. A woman who stretches Veneziano’s theory of quantum physics to its outer limit, challenging Taylor to prove that “everything is connected.”

A young woman, through sheer force of will, survives a brutal rape in Central Park. Detectives Stella Bonasera and Danny Messer’s mission to find the attacker is hindered, as the victim has no memory of the assault. Despite the abundant evidence at the crime scene, the detectives cannot connect a suspect to the rate, frustrating Stella, who commits herself to nailing the attacker. Meanwhile, Detective Mac Taylor and Aiden Burn must track down an evidence-swallowing rat when they investigate the shooting of a drug dealer. After inspecting the body, Dr. Sheldon Hawkes discovers that not only is the bullet missing, but that the victim has rat footprints and bites on his body. Now, the team needs to find one rate in a city with 70 million of them in order to gather the evidence that will lead them to the murderer.

A practical joke spirals into a murder mystery when a skeleton placed on a tour bus turns out to be authentic. As Detectives Mac Taylor and Stella Bonasera work to identify the skeleton and uncover its killer, the evidence leads them from Times Square, 2004 to Times Square, 1984; one unmistakable landmark, but two very different periods in New York City’s history.

When New York’s hottest DJ is found dead minutes before being crowned the undisputed “scratching” champion, Detective Mac Taylor is thrust into the world of “chirps, scribbles, and stabs.” The world of hip-hop. As the evidence leads Mac deeper into the web of the music industry, he uncovers how threats, intimidations and humiliations add up to a rising star with the best intentions becoming the industry’s latest casualty. Detectives Stella Bonasera and Danny Messer investigate the death of a fashion designer found dead in her penthouse pool. The case leads them to a sushi restaurant that specializes in food served on nude models.

When a construction worker dies in an explosion seven hundred feet below the streets of Manhattan, Detective Mac Taylor and Danny Messer go underground, entering the world of the ‘Sandhogs,’ men who burrow beneath New York City and live by the code: “At the end of the day every man comes out of the tunnel.” Meanwhile, Detectives Stella Bonasera and Aiden Burn examine the death of a 16-year-old who was found strangled and floating in a creek.

In a test of faith, Mac Taylor assigns Detectives Danny Messer and Aiden Burn to one of the team’s toughest cases yet: a multiple homicide in which employees of a Brooklyn restaurant are found shot to death with plastic bags over their heads. As they examine the clues, all signs point to an inside job but not to a suspect. Meanwhile, Mac and Detective Stella Bonasera investigate the death of a man found dead in his bed, whose amputated lower leg led them to him.

A Chinatown robbery by three men goes south when one security guard is killed and the other mistakenly fires shots at a gas tank, burning two of the robbers alive. While investigating the heist, Detective Stella Bonasera uncovers a kidnapping plot involving the bank's manager. Making matters worse, the kidnappers' ransom drop spot is blocked by an unannounced police terrorist response drill, forcing the team to uncover new clues to find the missing child.

Panic ensues on the floor of the New York Mercantile Exchange when a briefcase is left behind with no owner. The briefcase's contents are traced back to a stockbroker who mysteriously disappeared after investigating another broker’s illegal trades. Detective Mac Taylor has to piece together the cryptic evidence to solve a larger mystery and learns there’s a thin line between the man working The Street and the man living on the street. Meanwhile, Stella investigates the death of a pregnant counselor found next to the church where she worked.

When a mounted New York City police officer is shot off his horse, Detective Mac Taylor and the team comb the city for suspects. The only shard of evidence is the bullet lodged in the horse. Mac must make the painful decision to either save the animal or analyze the evidence. Meanwhile, in the Borough of Queens, the murder of a young man takes Aiden Burn to an Italian restaurant that’s cooking up a lot more than just pizza.

The brutal stabbing of a young woman leads Detectives Mac Taylor and Stella Bonasera into Stuyvesant Town, the middle-class epicenter of New York City. A female neighbor, covered in blood, appears to be the killer. But under the cover of darkness, all is not as it seems, as Mac explores the difference between unconscious motivation and conscious action.

The electrocution of a young man on the third rail of the New York City subway system in Brooklyn leads Detective Mac Taylor and Stella Bonasera into the world of an extreme sport where taking risks is part of the game. In Manhattan, Detective Danny Messer finds himself in a high stakes game of another sort, investigating the murder of an art dealer who just sold a painting that was apparently destroyed 190 years ago in a fire. In addition, when a non-union worker is found dead in Queens, Aiden Burn learns the hazards of construction work extend far beyond the actual site.

Competitive dog owners become the prime suspects in a murder investigation when Detective Mac Taylor examines the death of a dog trainer. Meanwhile, Detectives Stella Bonasera and Danny Messer track the killer of a bike messenger who collapsed on the streets of Manhattan after being stabbed during rush hour traffic. The team hits a roadblock when they must find the crime scene within a 4.8-mile delivery route.

The investigation of a suburban kid found beaten to death in the snowy woods of Van Cortland Park leads the CSI New York team to Tanglewood, home to small group of wannabe gangsters. Danny Messer, a native of this area, believes the neighborhood is not simply a place, but a culture. The case takes a turn when Detective Mac Taylor discovers Danny’s Tanglewood roots may run deeper than he ever imagined. On the other side of town, Danny Messer and Aiden Burn investigate a tangle of another sort when a woman from an Asian massage parlor is found dead in a mysterious hit and run.

Detectives Mac Taylor and Stella Bonasera uncover the body of a teenaged boy crammed into a 2’ x 2’ x 2’ box buried in the sand at Coney Island. This unusual body dump grows stranger when detectives learn not a single bone in the victim’s body was broken. Evidence from the box leads the CSI New York team to the City Circus. There, under the big top, lies the answer to this mystery. Meanwhile, a mysterious pool of blood found in a Soho apartment leads Danny Messer on a search for a missing woman, apparently found dead in her apartment.

Detectives Mac Taylor and Danny Messer find themselves on the trail of an elusive killer when an expectant bride drops dead on her wedding day. As the case unravels, the detectives discover the victim may have picked a killer dress. In Staten Island, the case of an ex-con found dead in an abandoned monastery sounds like a local ghost story, but Detective Stella Bonasera discovers the crime is real and the motive is revenge.

An 18-wheeler leaving the New York harbor is not only a target for robbery, but a perfect cover for murder. While investigating this truck-jacking, Detectives Mac Taylor and Stella Bonasera uncover a body pan caked underneath ten tons of steel. Searching for answers, CSI New York detectives navigate the dangerous world of New York longshoremen. Danny Messer and Aiden Burn investigate constriction of another sort when the body of a nude woman leads them into Manhattan’s seedy world of sexual fetishism, where their perceptions of “normal” are literally turned upside down. The victim had a forniphilia fetish. She was a hood ornament and died when her husband lost control of the car.

When young gang members murder the owner of an upscale Bronx wine store, the CSIs must work to find evidence that ultimately ties someone to the crime. Before dying, the store owner makes a statement to police identifying his attackers as young gang members. Tempers flare when the murder investigation reunites Detective Flack with his long-time mentor and friend Sergeant Gavin Moran, who was the first to arrive at the crime scene. Meanwhile, Danny and Aiden investigate the death of an influential movie producer found dead on the canopy of his Chelsea apartment building.

A celebration marking the release of a report on police corruption ends in bloodshed, when shots ring out on the 65th floor of a Midtown Manhattan high rise. Among the dead is one of the Precinct’s own men. To find the killer Mac Taylor and the CSI: New York team must track an elusive sniper with helicopter armed with rifles. Manning the machine was a jealous internal affairs inspector who lost his woman to the commissioner. Across town in Queens, Danny Messer and Aiden Burn investigate the murder of a gypsy cab driver, who travels in neighborhoods where others fear to tread. They learn the driver lost his life trying to protect a stripper from a rapist. The case provides an important lesson to both Danny and Aiden about the City’s everyday heroes.

Detective Mac Taylor and Stella Bonasera discover a dead woman among the sheets at an industry laundry facility. The evidence from the case leads them to a United Nations Diplomat and a man who reenacted a murder the diplomat committed ten years ago, proving that "he who has patience sees his revenge." Two Swedish tourists get a surprise when they place money into the tip jar of a "Human Statue" street performer, only to discover he¡¦s a dead body. When the autopsy reveals the man died of natural causes, Danny Messer becomes determined to find the person who used a dead homeless man as a human statue and finds a street performer who only wanted a day off.

The home invasion murder of a working class college student sends Detectives Mac Taylor and Stella Bonasera on the trail of China White, uncut heroin that has fallen into the wrong hands. On the streets of New York, this drug could prove deadly and leads Mac and Stella on a chase to find the drug before it claims the lives of unsuspecting users. Uptown and downtown intersect on a college campus, when the CSI: New York team track the drugs back to a sheltered college girl who found the drugs in a purse purchased from a street vendor. Because her parents have frozen her credit cards, she sells the drugs for some easy money. She doesn’t realize the vendor is a dealer who peddles his wares in plain sight, but Mac and Stella know this buyer proves, “What you don’t know can hurt you.”

When an armed suspect is uncovered at a secured crime scene, Danny Messer’s routine investigation quickly becomes a foot pursuit through the subway tunnels of New York City. Caught in the crosshairs, Danny opens fire, but upon investigation learns the man he shot is an undercover cop. Officers and witnesses believe Danny killed the wrong guy and it’s up to Mac to prove otherwise. On the other side of town, the murder of a nanny leads Stella Bonasera into the startling world of those who care for the privileged children of the Upper Westside. She discovers the victim was trying to back out of a theft ring among the nannies, when one of them killed her.

When the investigation of a vehicular homicide victim collides with a Boston baseball fan found dead in a New York parking lot, Detective Stella Bonasera discovers both victims had one thing in common: New York’s pro ball team. An up and coming pitcher gets humiliated at a game and throws a fast ball at a fan, rupturing his spleen. Mac faces his personal demons when a defendant facing trial insists that the CSI: New York team, “got it wrong.”

When a casual breakfast turns into a shootout, Detective Mac Taylor must put the pieces of the crime back together. Mac follows the evidence to a federal informant with a “get-out-of-jail-free” card and “nine lives.” To bring him down, Mac and Stella Bonasera must crack a counterfeit ring and render the informant useless to the feds.