When a highly efficient team of bank robbers pulls off a bank heist to steal a single safety deposit box, the job becomes personal for the CSI team when one of their own is shot and killed. Meanwhile, Grissom makes a major decision regarding his hearing problem.

When the CSI team is called to the Sphere Hotel to investigate a double homicide, they scour hotel’s security tapes for clues into who may be responsible for the murders. Meanwhile, Nick potentially jeopardizes the investigation by discussing specifics of the case, which later turn up on the local news -- giving the murderers insight into the investigation. Later, the team discovers another couple murdered in a similar fashion and they determine that they are looking for a serial killer.

The bodies of two gambling cheats are discovered shot execution style, shortly after being caught scamming several of Sam Braun's casinos, making Sam the number one murder suspect. Grissom is forced to take Catherine off the case because of her biological tie to Sam.