Grissom works a nightclub shooting with Greg Sanders, who finally found a replacement in the lab and now only has to pass his final proficiency test. Catherine investigates a stripper found dead in a hotel room. Warrick investigates a man found electrocuted in his bathtub. Sara and Nick are called in when an 'alien' is found in a shallow grave near Area 51.

The CSIs investigate when a thunderstorm washes up a body in the city storm drains. Murder is soon ruled out, but the team makes another disturbing discovery: human bones that may have come from a murder. The only problem is finding the location where the body was dumped.

The CSIs investigate the kidnapping of a 13-year old girl at the parking lot of a convenience store, which turns into a very disturbing murder. Catherine attempts to re-assert her role as a mother when her daughter Lindsey has been picked up by the police for hitchhiking.

When two apparently unrelated women die under the same circumstances, Catherine and Nick discover that both women underwent various cosmetic procedures at a local Spa. Meanwhile, Grissom, Sara and Greg investigate when a man is found dead in a house fumed for termites.

Grissom, Sara and Greg investigate when a woman is found dead in the fountain of a gated community, after visiting a neighborhood swingers party. Meanwhile, Warrick and Nick investigate the murder of a landlord in a video arcade, which develops into a double homicide. Catherine requests the position of day shift supervisor from Grissom.

While investigating a chopped up body on the University Grounds, the team finds out that they're dealing with the "Blue Paint Killer" again. The case gets confusing when the team finds out that the victim was male. Shortly after that they find another body, female. Can they stop the killer before he kills again?

Grissom has to work with Dayshift CSI Sofia Curtis when a high school student is found dead in a hotel room after a party. Assisted by Catherine, Nick and Warrick, they find out that another girl had been kidnapped from the party. However, the father of this girl doesn't seem overly concerned about his daughter's disappearance.

The CSI team investigate when a woman is found stabbed to death. They soon discover that the woman underwent a sex change operation and have to delve into the world of the Las Vegas transgender community to find the killer.

When an unknown fingerprint suddenly appears on a piece of evidence in court, Grissom must re-open the case and find the real culprit. However, this unexplained phenomenon causes Ecklie to doubt Grissom's handling of the case. Ecklie then opens an inquiry on Grissom, and questions each of the CSIs about his effectiveness as supervisor. Meanwhile, Sara and Greg investigate the circumstances surrounding the death of a man who shot himself in the leg.

Grissom and his team work on a case of a young boy found dead in a dumpster while Catherine and her team try to find out why an inmate was left braindead after an action by police.

Greg is doing his final proficiency test and he has a case to solve. Ironically, he investigates the death of a Sherlock Holmes wannabe who is obsessive to the point of recreating the great detective's living room in his home. He died from a close-range gunshot wound. The murder weapon is not found in the scene although everything other pieces of evidence suggest that it was a suicide. Working under Catherine, Nick and Warrick works on a case of a dead guy found in his car which veered off the highway. Dr. Robbins cannot find the cause of death and it is left to the two detectives to solve the mystery.

Catherine and Nick investigate a case when a severed head containing a snake is found in a newspaper stand. Warrick, Sofia and Greg investigate a shooting in a van.

When two bodies covered in tar are found, the CSIs must try to uncover the identity and the murderers. Sara is reprimanded by Ecklie for improper conduct.

Catherine and her team investigate when a hunter and a Kodiak bear are found dead in the mountains. Meanwhile Grissom's team look into the death of a young mother.

When Grissom and Catherine's teams work together to investigate the death of a famous casino owner, their investigation leads them to the bizarre world of infantilism.

Grissom and his team are looking for a murderer at a convention for plus-sized people. Catherine and her team investigate the world of sports betting when a man is found dead in the woods.

Grissom and his team investigate a case where a stewardess has been violently raped and stabbed to death in her hotel room, in which Ecklie discovers parallels to a five year old cold case. Catherine's team assists Detective Cavaliere in the investigation of a young boy beaten to death in his own bed, but Nick and Cavaliere get into a bitter disagreement over their methods of finding the culprit.

Greg, Sara, and Gil Grissom investigate a scene of bush fire which led to the death of man and the 3rd degree burn of another woman. Catherine, Nick and Warrick solve a case involving the death of an entire family. The father is found dead, apparently from a suicide, on his bed. The mother was shot while running downstairs. Their little daughter drowned to death in the pool.

It's a busy night in the lab as the CSIs investigate four cases: A hit and run involving a stolen Hummer, the murder of a Convention Girl, the death of a body builder, and the death of a boy found on a bench.

Captain Jim Brass journeys to LA after Ellie asks for a favor in investigating her friend's disappearance. There, with the help of Warrick who is in LA for a conference and a friend in LAPD, Brass finds his investigation interrupted by higher powers. While he and Warrick ultimately are able to find Ellie's friend's murderer, he is unable to bring the perpetrator to trial. Disappointed, he leaves LA and return to Las Vegas.

Sara accompanies Grissom to a mental hospital where one of its inmates has been murdered inside his room. Interviewing patients prove to be harder than usual as most of them are mentally unstable. While the two CSIs are there, they uncover more than just the crime. One of the most shocking discoveries involve a patient with a dark childhood, which is still haunting him, and a nurse with a secret.

After an exhaustive day, Catherine stops by a bar where she has a fling with another customer. As she is leaving, he gives her his number on the bar's match box. Later on that night, Grissom calls in for a favor as he is short on staff. A woman was murdered. Prior to her death, she was seen with the same man who was hitting on Catherine in the same bar. A similar match box with a phone number inside, found on the victim, further points to this man as the main suspect.

Sara and Greg investigate the death of two students in a dorm room. Nick, Warrick and Catherine investigate a man found dead in a 'crop circle.' Ecklie has to find out what happened to the corpse in the case he was working on when it turns up missing.

CSI Nick Stokes is kidnapped while investigating a crime scene and buried alive in a glass casket by his kidnapper. The Las Vegas Police Department receives a package with a tape and a USB key which allows them to watch Nick inside the casket, together with a request of one million dollars cash to release him. The mayor refuses to pay the ransom, but Catherine Willows convinces her wealthy father to provide the money. Gil Grissom schedules a meeting with the criminal to deliver the money and be informed where Nick is.

After Grissom gives the kidnapper the ransom money, the kidnapper blows himself up without revealing where Nick is buried. The team must then use all their knowledge and resources, as well as race time, to find Nick before he runs out of air.