A woman on vacation in Key West goes missing without a trace. Her husband calls police but a canvas of the area turns up nothing. Adding to the concern is the woman’s medical condition – she has not taken her blood pressure medication and every minute counts.

Larry McNabney, a wealthy California attorney, vanishes from a horse show. Interviews with friends and family yield multiple leads, ranging from financial trouble to a disgruntled former client. But just as it seems investigators are starting to pick up the trail, McNabney’s wife shockingly disappears. Are police dealing with a second kidnapping? Have the McNabneys simply fled their life? The shocking answers would lead to a cross country manhunt.

When a young mother fails to pick her son up from school, her family immediately knows something is wrong and calls police. Just as the search gets underway, her car is found abandoned and set on fire. Investigators quickly come up with multiple scenarios: the woman has been in an accident; she has been kidnapped and someone burned the crime scene; she has run away from her life and set the fire herself. But then a new discovery in the area only adds to the confusion: a second car in flames.

A mystery at sea leads investigators into a world where nothing is as it seems. Has a man vanished without a trace because of a tragic diving accident, or is there a sinister reason for his disappearance? The search covers thousands of miles, but what it uncovers would be the most shocking.

A college student disappears without a trace. Police follow every lead but to no avail. The young woman has simply vanished. Years go by and the mystery remains unsolved, but one determined lawman refuses to give up the search. And what he ends up finding would shock everyone.

Ronda Clever vanishes from her Missouri neighbourhood during her daily morning jog. With help from an eyewitness, local authorities pinpoint Clever’s last known location – a bridge located along her jogging route. Evidence recovered at the scene points to abduction. Racing the clock, police mobilize a massive search of the surrounding area, but it turns up nothing. The ensuing three year investigation would uncover a mysterious pick up truck, a secret storage unit and another missing woman.

Denise Bolser’s husband arrives home from work to find his wife missing and a ransom note taped to their refrigerator. Knowing that every passing hour in a kidnapping case is crucial, police immediately begin tracking Bolser’s final known movements, and set up surveillance, install phone taps and put out an all points bulletin. But hours turn to days, and days slip into weeks. With each passing year the chance of finding Denise Bolser gets slimmer and slimmer until nearly all hope is lost. For nearly two decades, dogged detectives refuse to give up on the case in the hopes of finding some form of closure for Bolser’s family. But they are stunned by what they actually end up finding.

A man about to get married disappears without a trace. Extensive police searches yield nothing, and the whereabouts of the missing man remain a mystery. But then, a dark secret changes the whole investigation. Can police find him before its too late?